Maternal serum TXNDC5 levels and thiol/disulfide homeostasis in preeclamptic pregnancies

Kaya B., Turhan U., Sezer S., Bestel A., Okumuş Z. G., Dağ İ., ...Daha Fazla

Journal of Maternal-Fetal and Neonatal Medicine, cilt.33, sa.4, ss.671-676, 2020 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/14767058.2018.1557140
  • Dergi Adı: Journal of Maternal-Fetal and Neonatal Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.671-676
  • Anahtar Kelimeler: Cellular apoptosis, oxidative stress, preeclampsia, protein misfolding, thiol/disulfide homeostasis, TXNDC5
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objective: To investigate thiol/disulfide homeostasis (TDH) and thioredoxin domain-containing 5 (TXNDC5) level in early and late-onset preeclampsia. Material and methods: In this cross-sectional study, 24 pregnant women with early-onset preeclampsia and 26 pregnant women with late-onset preeclampsia were compared with 30 pregnant women with no obstetric complications. The serum TXNDC5 levels and thiol/disulfide homeostasis were measured. Results: Serum TXNDC5 levels were significantly higher in the early-onset and late-onset preeclampsia groups compared with the control group (p <.05). Native thiol and total thiol levels were significantly lower in the early-onset and late-onset preeclampsia groups than control group. The disulfide levels were found as significantly high in early preeclamptic patients compared to control group (p <.05). The highest levels of TXNDC5 and the lowest levels of native thiol and total thiol were found in early-onset preeclampsia group. No significant difference was found between the patients with early onset and late onset preeclampsia regarding TXNDC5 levels and thiol/disulfide homeostasis (p >.05). Conclusion: Serum TXNDC5 levels were significantly higher in patients with early-onset and late-onset preeclampsia. The dynamic thiol/disulfide homeostasis was impaired in favor of the oxidized state in patients with preeclampsia.