Immunology in cardiology and pulmonary medicine clinics: Recent progress
Immunology in Clinic Practice, NOVA Publications , ss.45-74, 2011
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2011
- Yayınevi: NOVA Publications
- Sayfa Sayıları: ss.45-74
- Anahtar Kelimeler: Atherorosclerosis, Cardiac allograft vasculopathy, Lung immunology, Plaque formation, Rheumatic heart disease
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Inflammation seems to be important in both plaque formation and plaque rupture and many actors of innate and acquired immune system, other than T cells and monocytes, play a role in the atherosclerosis. There is growing evidence that cardiac allograft vasculopathy is primarily an immune-related response to transplantation although the mechanisms of cardiac allograft vasculopathy are not revealed completely. Rheumatic fever is the most common example of molecular mimicry in human pathological autoimmunity. Even though the pathogenesis of rheumatic fever is not completely understood, it is clear that an exacerbated immune response to bacterial antigens in susceptible hosts leads to autoimmune attack to several tissues and, in rheumatic heart disease patients; this triggers an inflammatory response to heart tissue, probably caused by molecular mimicry between group-A streptococcus antigens and heart tissue proteins. Pulmonary immune response induced by antigens divided into 3 phases. These are cognitive phase (defining and processing the antigen), activation phase (proliferation and differentiation of suitable lymphocytes to specific immune cells) and effector phase (regulation of immune responses of specific effectors lymphocytes to eliminate the foreign antigen). © 2010 by Nova Science Publishers, Inc. All rights reserved.