Side effects that cause noncompliance to antidepressant medications in the course of outpatient treatment Ayaktan izlenen hastalarda antidepresan tedaviye uyunçu bozan ilaç yan etkileri
Klinik Psikofarmakoloji Bulteni, cilt.24, sa.1, ss.69-75, 2014 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.5455/bcp.20120827114140
- Dergi Adı: Klinik Psikofarmakoloji Bulteni
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.69-75
- Anahtar Kelimeler: antidepressive agents, compliance, adverse effects
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Treatment non-compliance is defined as patients not following the treatment program as recommended by their physician. In studies, drug noncompliance for selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) has been found to be between 21-60%. Pharmacotherapeutic side effects were found to be responsible for approximately 30% of cases of non-compliance. In this study, we aimed to determine side effects that cause noncompliance in patients using SSRIs and TCAs. Method: The study group consisted of 264 patients, who were admitted to GATA Psychiatry outpatient clinic, in whom noncompliance was identified and who were using either SSRI or TCA treatments. Sociodemographic characteristics of the cases, medications they had used and causes of non-compliance were evaluated with a semistructured questionnaire. Results: It was found that 71 of the cases (26.8%) had discontinued the treatment due to side effects. No differences were found in terms of gender, age or educational level between the SSRI and TCA groups. The discontinuation rate due to side effects was higher in the somatization disorder subgroup medicated with TCAs. Moreover, there were no differrences within both groups with respect to discontinuation due to side effects or other causes. Conclusion: In this study, no significant differences were found between the two groups with respect to side effects that cause medication non-compliance. It was concluded that switching to another medication or informing patients adequately should be effective for prevention of noncompliance.