Maternal selenium status plays a crucial role on clinical outcomes of pregnant women with COVID-19 infection
Journal of Medical Virology, cilt.93, sa.9, ss.5438-5445, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 93 Sayı: 9
- Basım Tarihi: 2021
- Doi Numarası: 10.1002/jmv.27064
- Dergi Adı: Journal of Medical Virology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.5438-5445
- Anahtar Kelimeler: COVID-19, immunity, infection, pregnancy, selenium
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Adequate maternal selenium level is essential for immune response and healthy pregnancy. This study aimed to shed light on the selenium status of pregnant women with COVID-19 and the effects of potential deficiency in serum selenium levels. Totally 141 pregnant women, 71 of them were COVID-19 patients, in different trimesters were included in the study. Maternal serum selenium levels, demographic and clinical parameters were determined. Serum selenium levels of pregnant women in the second (p:.0003) and third (p:.001) trimesters with COVID-19 were significantly lower than in the healthy group. Maternal selenium level was found to be negatively correlated with gestational week (p <.0001, r: −.541), D-dimer (p:.0002, r: −.363) and interleukin-6 (IL-6) level (p:.02, r: −.243). In the second trimester, serum selenium level positively correlated with white blood cell (p:.002, r:.424), neutrophil (p:.006, r:.39), lymphocyte (p:.004, r:.410) count and hemoglobin (p:.02, r:.323), hematocrit (p:.008, r:.38) status. In the third trimester, it was found that maternal selenium level positively correlated with monocyte (p:.04, r:.353) and negatively correlated with C-reactive protein level (p:.03, r: −.384). Serum selenium level was gradually decreased during the pregnancy period, however, this natural decrease was enhanced together with COVID-19 infection. The reason might be increased selenium needs depended on the immune response against infection. The decrease in maternal selenium level was found to be related to IL-6 and D-dimer levels, which indicate selenium's role in disease progression.