Prognosis of Resected Non-small Cell Lung Cancer with Ipsilateral Pulmonary Metastasis
Thoracic and Cardiovascular Surgeon, cilt.68, sa.2, ss.176-182, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 2
- Basım Tarihi: 2018
- Doi Numarası: 10.1055/s-0038-1667169
- Dergi Adı: Thoracic and Cardiovascular Surgeon
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.176-182
- Anahtar Kelimeler: non-small cell lung cancer, intrapulmonary metastasis, satellite nodules, surgery, prognosis, tumor staging
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background Ipsilateral pulmonary metastasis (PM) in the same lobe (T3 Satell) or different lobe (T4 Ipsi Nod) constitutes a small proportion of patients with non-small cell lung cancer (NSCLC). In our study, we aimed to determine prognostic factors and to evaluate long-term survival outcomes in the patients who underwent complete resection due to NSCLC. Methods Data of 1,502 surgically treated patients with NSCLC from January 2007 to December 2016 were retrospectively reviewed. Fifty (3.3%) patients diagnosed with PM were the basis of the study. Demographic and histopathological characteristics, surgical procedures, and prognostic factors for survival were analyzed, categorizing patients according to the presence of PM in the same lobe or different lobe. Results Among the 50 patients, 23 (46%) had PM in the same lobe as the primary tumor and 27 (54%) had PM in different ipsilateral lobes. The mean size of nodules was 11.5 mm. While T3 Satell was detected mostly in squamous cell carcinoma (SCC) (65.2%), T4 Ipsi Nod was more common in adenocarcinoma (AC) (70.4%), and the difference was statistically significant (p = 0.022). Survival was significantly better in the SCC-T3 Satell group than the AC-T3 Satell group (64 and 58.3%, respectively; p = 0.043). Although the overall 5-year survival was better in the T3 Satell group, the difference between survival outcomes of both groups was not statistically significant (61.2 and 37.2%, respectively; p = 0.27). In the T3 Satell group, nodule size was found to be a negative prognostic factor in survival (p = 0.042), whereas the number of nodules was found to be a negative prognostic factor in the T4 Ipsi Nod group (p = 0.046). In multivariate analysis, advanced age was a poor prognostic factor for PM (p = 0.03). Conclusion There was no significant difference in survival between T3 Satell and T4 Ipsi Nod patients. Among surgically treated patients due to NSCLC, poor prognostic factors were advanced age for the patients with PM, nodule size and AC for T3 Satell patients, and the number of nodules for T4 Ipsi Nod patients.