Thrombocytopenia due to rivaroxaban: A rare adverse effect

Tığlıoğlu, Mesut; Akyol, Pınar; Sağlam, Buğra; Aras, Merih; AFACAN ÖZTÜRK, Hacer; Yıldız, Abdulkerim; ALBAYRAK, Murat

doi:10.1016/j.transci.2020.102883

Thrombocytopenia due to rivaroxaban: A rare adverse effect

Tığlıoğlu M., Akyol P., Sağlam B., Aras M. R., AFACAN ÖZTÜRK H. B., Yıldız A., ...Daha Fazla

Transfusion and Apheresis Science, cilt.59, sa.6, 2020 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 59 Sayı: 6
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.transci.2020.102883
Dergi Adı: Transfusion and Apheresis Science
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
Anahtar Kelimeler: Atrial fibrillation, Rivaroxaban, Drug-induced thrombocytopenia, Side-effect
Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Introduction: Rivaroxaban is a novel, oral direct acting anticoagulant (DOAC) that is used for both treatment and prevention of thromboembolic diseases. Due to mechanism of action; most common side effect may be seen with hemorrhage. Here in we reported that a patient with chronic atrial fibrillation presented with thrombocytopenia while taking rivaroxaban. Case report: A 76-year-old female patient with atrial fibrillation was given rivaroxaban, after lack of dose administration of warfarin and gastrointestinal bleeding. In 12th dayweek of treatment, the patient was admitted to emergency department (ED) with oral mucosal bleeding and petechial spots.The patient diagnosed as Drug-induced Thrombocytopenia (DITP)due to rivaroxaban use, after ruled out most possibilities ofITP (immune thrombocytopenic purpura). After rivaroxaban is discontinued, the patient's bleeding complaints regressed,symptoms were completely resolved, and platelet count rapidly increased towards physiological level in days. The patient is currently in the 6th month of follow-up and is has no bleeding. Conclusion: To the best of our knowledge there are only two cases about rivaroxaban induced thrombocytopenia (RIT). In addition to the well-known side effects ofrivaroxaban treatment, it should be kept in mind that thrombocytopenia may also develop.Naranjo adverse drug reaction probability scale calculated as 7 points.(probable cause for the patient's thrombocytopenia)