Choroidal Vascularity Index as a Potential Inflammatory Biomarker for Obsessive Compulsive Disorder
Ocular Immunology and Inflammation, cilt.30, sa.2, ss.428-432, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.1080/09273948.2020.1800052
- Dergi Adı: Ocular Immunology and Inflammation
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.428-432
- Anahtar Kelimeler: Obsessive compulsive disorder, inflammatory markers, choroidal vascularity index, choroidal thickness, NLR
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: To evaluate choroidal vascularity index (CVI) and to investigate the association of CVI with neutrophil-to-lymphocyte ratio (NLR) as an indicator of inflammation in obsessive-compulsive disorder (OCD). Material and Methods: This prospective study included newly diagnosed OCD patients and healthy controls. All patients underwent EDI-OCT imaging to assess the subfoveal choroidal thickness (sCT) and peripapillary CT (pCT). CVI was defined as the ratio of luminal area to stromal area after binarization on EDI–OCT images. Results: A total of 39 patients with OCD and 25 controls were included. The sCT, pCT, and CVI values were significantly higher in the OCD vs. control group (p˂0.05 for all). The NLR values were significantly higher in the OCD vs. control group (p = .007). A significant positive correlation was noted between CVI and NLR (p = .039). Conclusion: Our findings suggest that systemic inflammation may play a role in the pathogenesis of OCD.