Survival and mortality risk factors in chronic obstructive pulmonary disease: A three-year cohort analysis
Eurasian Journal of Pulmonology, cilt.28, sa.2, ss.92-102, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.14744/ejp.2025.56336
- Dergi Adı: Eurasian Journal of Pulmonology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO)
- Sayfa Sayıları: ss.92-102
- Anahtar Kelimeler: Chronic airway diseases, chronic obstructive lung disease, chronic obstructive pulmonary disease, survival
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
BACKGROUND AND AIM: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability worldwide. Precise survival estimates and identification of mortality risk factors are crucial for managing COPD. This prospective study aimed to investigate the survival rate and identify predictors of mortality in patients with COPD. METHODS: We investigated the association of various factors with three-year survival rates in our COPD cohort. Patients (n=176) underwent baseline assessments including demographics, comorbidities, questionnaires, laboratory findings, and long-term oxygen therapy/bilevel positive airway pressure (LTOT/BPAP) use. The primary endpoint was completion of three-year follow-up, and the secondary endpoint was all-cause mortality. Cox regression analysis was used to explore factors associated with mortality. Survival analysis was performed using the Kaplan-Meier method. RESULTS: This prospective cohort study of 176 COPD patients (65.4 years old, mostly male) identified a three-year overall survival rate of 86.4%. Age ≥68.5 years (p<0.001), Charlson Co-morbidity Index (CCI) scores ≥4.5 (p<0.001), and eosinophil counts ≤45 cells/μL (p<0.001) were independently associated with poorer survival. LTOT use (p=0.001) was also associated with reduced survival. CONCLUSIONS: In this prospective cohort study, age, CCI, LTOT use, and baseline eosinophil count were associated with survival and identified as predictors of mortality. An age cut-off of ≥68.5 years and a CCI cut-off score of ≥4.5 were associated with increased mortality risk, while lower baseline eosinophil counts (cells/μL) predicted poorer survival in this COPD cohort.