Virilizing Adrenocortical Carcinoma Oncocytic Variant in a Child with Heterosexual Precocious Puberty and a Literature Review
Journal of Pediatric Research, cilt.9, sa.3, ss.307-313, 2022 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 3
- Basım Tarihi: 2022
- Doi Numarası: 10.4274/jpr.galenos.2022.05579
- Dergi Adı: Journal of Pediatric Research
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.307-313
- Anahtar Kelimeler: Oncocytic variant adrenocortical cancer, peripheral precocious puberty, clitoromegaly
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Androgen-secreting adrenal tumors are aggressive cancers in childhood; however, they are rare in clinical practice. Children with adrenal carcinoma usually present with peripheral precocious puberty, premature pubarche, signs of virilization and clitoromegaly. We present a case of 4 year-old girl with premature pubarche, clitoromegaly and bone age advancement, who was subsequently diagnosed with pure androgen-secreting oncocytic adrenal carcinoma. After the removal of the adrenal tumor, our patient developed precocious puberty. In patients with functioning adrenocortical carcinoma who have had surgical removal, clinical follow-up and hormonal marker examination for the secondary effects of excessive hormone secretion at least every 2 or 3 months may be a useful option after surgery. The aim of this article is to emphasize that adrenal tumors can be seen in patients presenting with virilization findings. We also present a literature review of these tumors, which are very rare in childhood.