Prognostic importance of Bcl-2 expression in colon cancer Kolon kanserinde Bcl-2 ekspresyonunun prognostik önemi
Journal of Clinical and Analytical Medicine, cilt.4, sa.5, ss.404-407, 2013 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 4 Sayı: 5
- Basım Tarihi: 2013
- Doi Numarası: 10.4328/jcam.1138
- Dergi Adı: Journal of Clinical and Analytical Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.404-407
- Anahtar Kelimeler: Colon Cancer, Prognosis, Bcl-2, Immunohistochemistry
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: TNM classification, that had been established according to pathologic and anatomic characteristics of the lesion, is the most important factor in decision of adjuvant therapy in colon cancer. Despite curative resection, recurrence can ocur with a rate of 20-30% in early stage disease. Therefore efficieny of TNM classification is controversial. In recent years,significance of molecular characteristics of the tumors besides their anatomic and pathologic characteristics in determining the biological behaviour and response to treatment have been discussed. In our study, relation between expression of Bcl-2 and the other known prognostic factors in colon cancer had been searched. Material and Method: Patients who had been followed up in our clinic were enrolled in this study. Expression of Bcl-2 was searched by immunohistochemical method. Results: A total of 52, 19 (%36.5) female and 33 (%63.5) male patients were enrolled in this study. Bcl-2 expression was found positive in 7 (%13.5) and negative in 45 (%86.5) patients. Statistically no significant relationship was found between Bcl-2 expression and sex, stage, regional lymph node involvement, presence of distant metastasis and histologic grade. Discussion: In our study, although not in a statistical significance, we found that Bcl-2 expression is related to early stage disease. Bcl-2 is a low-priced and easily accessible prognostic marker. We think that establishing expression of Bcl-2 by immunohistohemistry may play a role in determining prognosis of patients with colon cancer.