Microwave-and ultrasound-promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities
Journal of the Turkish Chemical Society, Section A: Chemistry, cilt.7, sa.1, ss.25-36, 2019 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 1
- Basım Tarihi: 2019
- Doi Numarası: 10.18596/jotcsa.563286
- Dergi Adı: Journal of the Turkish Chemical Society, Section A: Chemistry
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.25-36
- Anahtar Kelimeler: ADME prediction, Antioxidant Capacity, Antiurease Inhibiton, Microwave Irradiation, Thiazole, Ultrasound Sonication
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Six thiazolyl-pyrazoline derivatives were synthesized starting from corresponding chalcone compounds for their antioxidant capacity and antiurease inhibitory activities. In addition to the conventional method, ultrasonic sonication and microwave irradiation methods which are environmental methods were used in the synthetic stage. Compound 2-(5-(3-bromophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenyl thiazole (5a) exhibited the most potent antiurease activity with IC50 of 2,28±0,02, which was comparable to the positive control.