Serum YKL-40 Level in Pregnant Women with Gestational Diabetes Mellitus Gestasyonel Diyabetes Mellituslu Gebelerde Serum YKL-40 Düzeyi
Sakarya Medical Journal, cilt.12, sa.1, ss.92-97, 2022 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 1
- Basım Tarihi: 2022
- Doi Numarası: 10.31832/smj.948949
- Dergi Adı: Sakarya Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.92-97
- Anahtar Kelimeler: GDM, HOMA-IR, insulin resistance, YKL-40
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction To clarify its role on insulin resistance in pregnant women with GDM and by measuring the level of YKL-40 in maternal serum. Materials and Methods Results Conclusion Between June 2012 and June 2013, 40 GDM and 40 healthy pregnant women were included in the study. Demographic and clinical parameters of pregnant women were obtained from patient files. Fasting glucose, HbA1c, fasting insulin and YKL-40 levels were measured in these pregnant women. The HOMA-IR value was calculated. The parameters of GDM and healthy pregnant women were compared. The relationship between serum YKL-40 level and insulin resistance parameters was investigated. There was no statistical difference between GDM and healthy pregnant women in terms of age, systolic and diastolic blood pressure, gestational week, birth weight, leukocyte count and fasting glucose level (p> 0.05 for all). BMI, HbA1c, fasting insulin level, HOMA-IR value and YKL-40 level were found to be statistically significantly higher in pregnant women with GDM compared to healthy pregnant women (31,8 ± 4,3, 28,1 ± 2,4, p:0.001; 5,86 ± 1,85, 5,11 ± 0,25, p:0,001; 12,74 ± 6,52, 7,44 ± 2,12, p:0,001; 3,12 ± 1,94, 1,81 ± 0,48, p:0,001; 82,9 ± 11,4, 56,5 ± 9,2, p:0,001; respectively). Serum YKL-40 level was positively correlated with BMI, HbA1c, fasting insulin and HOMA-IR value (r:0.507, p:0.001; r:0.668, p:0.001; r:0.556, p:0.001; r:0.379, p:0.009, respectively). It was determined that serum YKL-40 level increased in pregnant women with GDM and this level was positively correlated with insulin resistance parameters.