Aortic valve replacement in a patient with β-thalassemia β-Talasemili Hastada Aort Kapak Replasmam
Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi, cilt.23, sa.4, ss.153-156, 2017 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 4
- Basım Tarihi: 2017
- Doi Numarası: 10.5222/gkdad.2017.153
- Dergi Adı: Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.153-156
- Anahtar Kelimeler: Anticoagulant therapy, Aortic Valve Replacement, Pulmonary hypertension, β-thalassemia
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Heart valve diseases can be seen as a consequence of elastic tissue defect in β-thalassemia patients. The possibility of pulmonary complications and rapid thrombosis of the prosthetic valve after valve replacement should be considered in these patients. In this case report, we aimed to present our experience of aortic valve replacement in a patient followed up with a diagnosis of β-thalassemia. Transthoracic echocardiography of a 27-year-old male patient followed-up with the diagnosis of β-thalassemia major revealed severe aortic stenosis and regurgitation, left ventricular dysfunction (EF: 40%), left ventricular dilatation and maximum systolic pressure gradient of 80 mmHg across the aortic valve. Pulmonary artery pressure was 55 mmHg. According to his medical history, he had undergone splenectomy at age 17. Aortic valve replacement was scheduled for the patient and bileaflet mechanical valve replacement was performed. A total of 3 units of erythrocyte suspension were transfused within 24 hours postoperatively. Postoperative transthoracic echocardiography showed normal aortic valve function and a maximum systolic gradient of 15 mmHg. The patient was started on Coumadin with a target INR of 3.0 to 3.5. He was discharged on the 5th postoperative day. Close follow-up after valve replacement is required, considering the increased tendency to thrombosis in patients with β-thalassemia. Appropriate anticoagulant therapy should be planned by evaluating the predisposing factors in patients.