Effect of a bioresorbable membrane on postoperative adhesions and wound healing
Journal of Reproductive Medicine for the Obstetrician and Gynecologist, cilt.48, sa.7, ss.547-550, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 7
- Basım Tarihi: 2003
- Dergi Adı: Journal of Reproductive Medicine for the Obstetrician and Gynecologist
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.547-550
- Anahtar Kelimeler: adhesions, wound healing, Seprafilm
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: To study the effect of Seprafilm (Genzym Corporation, Cambridge, Massachusetts), a biosorbable membrane, on adhesion formation and injury recovery. STUDY DESIGN: Twenty female Wistar-albino rats were divided into two groups of 10 each. The right uterine horns of all rats were incised longitudinally and then stitched. While no procedure was conducted in group I (control group), in group II (Seprafilm group) this incision line was wrapped with Seprafilm. The rats were reoperated on day 7 after the first operation. The results were assessed using the Mann-Whitney U (MWU) test, and P <.05 was considered significant. RESULTS: The adhesion score in group I was higher than in group II (3.6±0.1 vs. 0.3±0.1; P=.000, MWU test). In the histopathologic examination performed to examine injury recovery, the measured bursting pressures and hydroxyproline levels were similar in the two groups. CONCLUSION: Seprafilm prevented postoperative adhesions without affecting injury recovery and thus can be used reliably.