Systemic oxidative stress biomarkers in patients with vitreomacular traction syndrome
International Ophthalmology, cilt.41, sa.11, ss.3789-3796, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41 Sayı: 11
- Basım Tarihi: 2021
- Doi Numarası: 10.1007/s10792-021-01949-0
- Dergi Adı: International Ophthalmology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
- Sayfa Sayıları: ss.3789-3796
- Anahtar Kelimeler: Malondialdehyde, Oxidative stress, Total antioxidant status, Total oxidant status, Vitreomacular traction syndrome
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To evaluate whether the systemic oxidative stress biomarkers increased in patients with vitreomacular traction syndrome (VMT). Methods: This study compared 25 patients diagnosed with VMT with 20 healthy controls. As a biomarker of systemic oxidative stress, malondialdehyde (MDA) was measured. Total oxidant status (TOS) and total antioxidant status (TAS) were measured to evaluate the systemic oxidant status. Results: Serum MDA values were significantly higher among the patients (p < 0.001). The ideal cut-off value for MDA was determined to be 22.1 µmol/L, with 80% sensitivity and 75% specificity. The between-group differences were not statistically significant for TOS or TAS (p = 0.326 and p = 0.698, respectively). Conclusion: Increased MDA levels suggest that systemic oxidative stress may play a role in VMT.