Induction of spermatogenesis in idiopathic hypogonadotropic hypogonadism with gonadotropins in older men
Archives of Andrology, cilt.50, sa.4, ss.267-271, 2004 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 4
- Basım Tarihi: 2004
- Doi Numarası: 10.1080/01485010490448732
- Dergi Adı: Archives of Andrology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.267-271
- Anahtar Kelimeler: gonadotropins, idiopathic hypogonadotropic hypogonadism, spermatogenesis, testicular sperm extraction
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
We investigated the treatment results in 6 azoospermic idiopathic hypogonadotropic hypogonadism (IHH) cases that remained untreated 41-47 years of age. Medical history, physical examination, hormone profile measurements, peripheral blood karyotype, skull X-ray and/or magnetic resonance imaging were performed. Patients received 1,000 to 5,000 IU hCG, 2-3 times per week, and 75 to 150 IU hMG, 2-3 times per week for 24 months. Serum testosterone levels were assessed every month for maximum 6 months to evaluate optimal dose of treatment and then every 3 months thereafter. Sperm counts were assessed every 3 months. Testosterone level increased from 2.7 ±0.9 mIU/L to 22 ±7.04 mIU/L with treatment; testicular volume increased by 4.6 ml during the treatment. Sperm were detected in the ejaculate in 3 out of 6 patients on the 22nd, 18th, and 15th month of treatment. 3 patients underwent testicular biopsy; histopathology revealed tubular hyalinization. Spermatogenesis in older men with IHH was restored by exogenous gonadotropins.