Use of a Collagen–Laminin–Based Dermal Matrix Combined with Resveratrol Microparticles (Dermalix) for Wound Complications After Breast Surgery

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AKYÜZ S., KILIÇ B., İpek K., GÜVEN H. E., BAHÇECİOĞLU İ. B., TURAN M., ...Daha Fazla

Acta Haematologica Oncologica Turcica, cilt.58, sa.3, ss.206-211, 2025 (Scopus, TRDizin)

Özet

Aim: Wound complications after breast surgery may adversely affect the healing process and delay the initiation of adjuvant therapy. Despite appropriate surgical technique and postoperative care, wound complications can still occur following breast operations. To evaluate the role of a collagen-laminin-based dermal matrix combined with resveratrol microparticles in the management of wound complications after breast surgery. Methods: This study was conducted in the Surgical Department of a Training and Research Hospital between March 2021 and March 2022, and included 15 patients who underwent breast surgery. Inclusion criteria were: (a) prior breast surgery; (b) postoperative wound complication; (c) presence of granulation tissue; (d) a microbiologically culture-negative wound; and (e) use of a collagen-laminin-based dermal matrix combined with resveratrol microparticles during wound care. Results: The mean age of the patients was 52.67±8.61 years. All were female. Wound complications occurred after breast cancer surgery in 73.4% of patients, while in 26.6% they were related to other surgical indications. Consecutive applications resulted in a statistically significant mean reduction in wound dimensions (p=0.012). Collagen-laminin-based dermal matrix combined with resveratrol microparticles showed a maximal effect by day 8 (after two consecutive applications), producing a marked decrease in wound size. No studies have evaluated the role of a collagen-laminin-based dermal matrix combined with resveratrol microparticles in wound complications after breast surgery. This study is the first to evaluate the therapeutic role of a collagen-laminin-based dermal matrix combined with resveratrol microparticles in wound complications after breast surgery. A characteristic feature of our study is that the patient population predominantly comprises individuals with wound complications following breast cancer surgery. Conclusion: Collagen-laminin-based dermal matrix combined with resveratrol microparticles may have a role in the ambulatory management of granulating wound complications with microbiologically clean wound beds following breast surgery. Larger multicenter randomized controlled trials are needed.