Successful treatment of an older patient with delayed neurological sequelae and delirium after carbon monoxide poisoning with memantine
Gulhane Medical Journal, cilt.68, sa.1, ss.59-62, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.4274/gulhane.galenos.2025.12989
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, EMBASE, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.59-62
- Anahtar Kelimeler: CO poisoning, delayed neurological sequelae, delirium, geriatrics, memantine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Carbon monoxide (CO) poisoning can cause delayed neurological sequelae (DNS), a condition with no effective treatment. We report a 66-year-old male patient who recovered from acute CO poisoning but developed DNS and delirium one week later. He showed akinetic mutism, parkinsonism, rigidity, and cognitive impairment. Non-pharmacological approaches and donepezil were tried, but due to side effects, memantine (20 mg/day) was started. Over the course of one year, the patient showed significant improvement in neurological and functional status, with improvements in cognitive function (Mini-Mental State Examination: 26) and brain magnetic resonance imaging findings. This case suggests memantine may contribute to DNS recovery.