Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones СИНТЕЗА И ИСПИТИВАЊЕ АНТИМИКОБАКТЕРИЈСКЕ И АНТИФУНГАЛНЕ АКТИВНОСТИ НОВИХ ДЕРИВАТА 4-(ФУРАН-2-ИЛМЕТИЛ)-6-МЕТИЛПИРИДАЗИН-3(2H)-ОНА

KARAYAVUZ, Burcu; Vagolu, Siva; Kart, Didem; Tønjum, Tone; ÜNSAL TAN, OYA

doi:10.2298/jsc230424040k

Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones СИНТЕЗА И ИСПИТИВАЊЕ АНТИМИКОБАКТЕРИЈСКЕ И АНТИФУНГАЛНЕ АКТИВНОСТИ НОВИХ ДЕРИВАТА 4-(ФУРАН-2-ИЛМЕТИЛ)-6-МЕТИЛПИРИДАЗИН-3(2H)-ОНА

KARAYAVUZ B., Vagolu S. K., Kart D., Tønjum T., ÜNSAL TAN O.

Journal of the Serbian Chemical Society, cilt.89, sa.11, ss.1423-1431, 2024 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 89 Sayı: 11
Basım Tarihi: 2024
Doi Numarası: 10.2298/jsc230424040k
Dergi Adı: Journal of the Serbian Chemical Society
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1423-1431
Anahtar Kelimeler: pyridazinone, furan, biological activity.
Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

This study reports the synthesis and evaluation of a series of new pyridazin-3-ones with furan moieties 5a–j and 6a–f, to test for their antimycobacterial and antifungal activities. The structures of the target compounds were confirmed by elemental analysis and spectroscopic techniques (IR, mass, 1H- and 13C-NMR). Amongst the compounds tested, 5e, 5g, 5i and 6e exhibited highest activity against Mycobacterium tuberculosis, while 5h, 6d and 6f showed moderate in vitro antifungal activities against Candida albicans and Candida parapsilosis.