The effect of iron deficiency anemia on plasma thyroid hormone levels in childhood Çocukluk çaǧında demir eksikliǧi anemisinin plazma tiroid hormonları üzerine etkisi
Turk Pediatri Arsivi, cilt.46, sa.2, ss.129-132, 2011 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 2
- Basım Tarihi: 2011
- Doi Numarası: 10.4274/tpa.46.59
- Dergi Adı: Turk Pediatri Arsivi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.129-132
- Anahtar Kelimeler: Anemia, Iron deficiency, thyroid hormone
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: Studies concerning thyroid functions in iron deficiency anemia, which is frequently seen in childhood, are limited. So, the present study was planned to investigate the effects of iron deficiency anemia on thyroid hormone metabolism. Material and Method: The study was approved by the Ethics Committee (number:77, 04.11.2008) and prospectively conducted among 90 patients with iron deficiency anemia (study group) and 38 healthy children (control group) aged between 1-14 years. Complete blood count, iron, iron binding capacity, ferritin, TSH, TT4, TT3, fT4, fT3 were determined from all the children included in the study. Social Package for Social Sciences (SPSS) 15.0 programme was used to analyze the data. Results: Gender and age distribution of the groups were not different while mean birth and height values of the study group were lower than the control group (p<0.001). TT3 and TT4 values were also statistically low in the study group (p=0.002, p<0.001, respectively). Comparing the fT4 and fT3 levels, there was no difference between the groups. There was a positive correlation between TT3-ferritin and TT3-transferrin saturation levels. Conclusions: Although our study suggests that iron deficiency anemia effects the total thyroid hormone levels, biologically active free thyroid hormone fractions are sustained within normal limits. Further studies are required to investigate the mechanism, reversibility and clinical perspective of this effect.