Assessment of insulin resistance in different phases of bipolar disorder with the triglyceride glucose index, triglyceride glucose-body mass index, and metabolic score index for insulin resistance
Brazilian Journal of Psychiatry, cilt.47, 2025 (SCI-Expanded, SSCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47
- Basım Tarihi: 2025
- Doi Numarası: 10.47626/1516-4446-2025-4179
- Dergi Adı: Brazilian Journal of Psychiatry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Fuente Academica Plus, BIOSIS, EMBASE, MEDLINE, Psycinfo, Directory of Open Access Journals
- Anahtar Kelimeler: Bipolar disorder, insulin resistance, TyG, TyG-BMI, METS-IR
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To determine whether there are differences in the parameters triglyceride glucose index (TyG), triglyceride glucose-body mass index (TyG-BMI), and metabolic score index for insulin resistance (METS-IR) between subgroups of patients diagnosed with bipolar disorder (BD) – in euthymic, manic, and depressive states – and healthy controls. Methods: A total of 238 patients diagnosed with BD and 90 healthy controls were included in the study. Results: TyG-BMI was higher in depressed-state BD patients than in manic-state BD patients. The METS-IR was significantly higher in depressed BD patients than in healthy controls. TyG-BMI was a statistically significant predictor of euthymic and depressed states of BD. In addition, the METS-IR was a statistically significant predictor of euthymic-state BD, depressed-state BD, and BD overall. In the receiver operating characteristic (ROC) analysis, we obtained the highest area under the ROC curve (AUC) values in the parameters TyG-BMI and METS-IR to discriminate the patient groups from healthy controls. Conclusion: This is the first study to provide evidence that elevated levels of METS-IR and TyG-BMI may be an indicator of IR in BD patients and can be used to differentiate BD patients from healthy controls. However, there is a need for confirmation of these results in larger studies before definitive conclusions can be drawn.