Can Native Thiol Levels be an Indicator to Determine the Severity of COVID-19 Cases? Nativ Tiyol COVİD-19 Olgularının Şiddetini Tespit Etmede Belirteç Olarak Kullanılabilir mi?
Medical Journal of Bakirkoy, cilt.19, sa.4, ss.389-396, 2023 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 4
- Basım Tarihi: 2023
- Doi Numarası: 10.4274/bmj.galenos.2023.2023.3-21
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL
- Sayfa Sayıları: ss.389-396
- Anahtar Kelimeler: Native thiols, COVID-19, malondialdehyde, myeloperoxidase, superoxide dismutase, glutathione peroxidase
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To investigate the possible relationship between the severity of the disease and some oxidant-antioxidant markers in patients diagnosed with coronavirus disease-2019 (COVID-19). Methods: A total of 130 cases with a diagnosis of COVID-19 were included in the study, classified as severe (group 1, n=65) and mild/moderate (group 2, n=65) and control group (group 3, n=54). Routine laboratory methods were used to analyze serum C-reactive protein, D-dimer, procalcitonin, and ferritin levels. In addition, the levels of oxidants, including malondialdehyde (MDA) and myeloperoxidase (MPO), as well as antioxidants, such as glutathione peroxidase (Gpx), superoxide dismutase (SOD), uric acid, and native thiol, were analyzed. The descriptive statistics of continuous variables were reported as the median with a range of minimum to maximum values. Furthermore, statistical tests such as the Kolmogorov-Smirnov and Mann-Whitney U tests were used. The chi-square test was used to investigate any statistical associations between groups and other categorical independent variables. To determine the significance, analysis of covariance (ANCOVA) was performed. Results: The results showed that both group 1 and group 2 COVID-19 patients had considerably higher levels of routine laboratory tests than the control group (p<0.001). Furthermore, significantly lower levels of native thiol were found in both groups 1 and 2 compared with the control group (p<0.001 for both). In addition, a significant difference was observed between group 1 and group 2, with group 1 showing markedly lower levels of native thiol (p<0.001). Conclusion: We concluded that the oxidative stress indicators MDA and MPO and the antioxidant indicators Gpx and SOD cannot be used to determine the severity of COVID-19, but decreasing natural thiol levels can be an indicator of disease severity in this population. In addition, these data may be important in explaining the mechanism of N-acetylcysteine therapy in COVID-19 cases.