Comparison of clinical features and surgical outcome in focal cortical dysplasia type 1 and type 2
Epilepsy Research, cilt.136, ss.130-136, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 136
- Basım Tarihi: 2017
- Doi Numarası: 10.1016/j.eplepsyres.2017.08.008
- Dergi Adı: Epilepsy Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.130-136
- Anahtar Kelimeler: Epilepsy surgery, Focal conical dysplasia, Epilepsy, Pathological subtypes
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction Recent ILAE classification defined focal cortical dysplasia (FCD) patients with accompanying epileptic lesions as a separate group. We investigated data of patients with sole FCD lesions regarding long-term seizure outcome and different characteristics of FCD type 1 and type 2 patients. Methods Eighty children and adult patients underwent surgery for FCD were included to the analysis of factors differentiating FCD type 1 and type 2 groups and their effect on long-term outcome. Results FCD type 2 patients had earlier epilepsy onset (8.1 vs. 6.1 years. p = 0.019) and underwent surgery younger than type 1 (18.2 vs. 23.7 years. p = 0.034). FCD type 2 patients were more prominently MR positive (77.8% vs. 53.8%. p = 0.029), which increased within FCD type 2 group as patients become younger (p = 0.028). FCD Type 1 lesions showed mostly multilobar extension and FCD type 2 mostly located in frontal lobe. Seizure freedom was achieved in 65.4% of FCD type 1 patients and 70.4% of FCD type 2 patients. Seven patients had permanent de novo neurological deficits. Mean follow-up time was 5.5 years (Range: 1–11 years). Conclusion Surgical intervention in carefully selected patients may facilitate favorable seizure outcome leading to better quality of life. FCD type 1 and type 2 groups present with evident differences, which may promote medical and surgical management of these pathologies.