Topical glucocorticoid reduces the topical decongestant-induced histologic changes in an animal model nasal mucosa
Laryngoscope, cilt.122, sa.4, ss.741-746, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 122 Sayı: 4
- Basım Tarihi: 2012
- Doi Numarası: 10.1002/lary.23207
- Dergi Adı: Laryngoscope
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.741-746
- Anahtar Kelimeler: Nasal mucosa, rhinitis medicamentosa, congestion, decongestant, nasal steroid, rebound, edema, Level of Evidence: 2c
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives/Hypothesis: To investigate the histologic consequences of simultaneous nasal glucocorticosteroid and xylometazoline HCl administration in the rabbit nasal mucosa. Study Design: Prospective randomized study. Methods: Twenty New Zealand male rabbits were randomly placed into three groups: group I, control (n = 6); group II, xylometazoline HCl (n = 8); or group III, xylometazoline HCl-fluticasone furoate (n = 6). Group I received no treatment. Groups II and III received two intranasal puffs of xylometazoline HCl 0.5 mg/mL twice daily or two puffs of xylometazoline HCl 0.5 mg/mL twice daily plus one puff of 27.5 μg fluticasone furoate twice daily to each nostril (110 μg), respectively. At the end of 3 weeks, the rabbits were sacrificed. The mucosa of the nasal cavities was excised. Specimen sections (5 μm) were stained with hematoxylin and eosin, mucicarmine, and Gomori one-step trichrome and were examined under a light microscope. The presence of edema, congestion, inflammatory cell infiltration, nasociliary loss, epithelial and nerve-ending degeneration, and goblet cell increase were evaluated semiquantitatively (grades 0-3). Results: Statistically significant differences were detected between groups II and III in terms of edema, congestion, inflammatory cell infiltration, nasociliary loss, and epithelial degeneration (P =.006, P =.049, P =.015, P =.014, and P =.049, respectively). Nerve-ending degeneration, goblet cell increase, and quantitative goblet and neutrophil cell counts did not yield statistically significant differences between groups II and III (P =.137, P =.580, P =.770, and P =.616, respectively). Conclusions: The combined simultaneous intranasal administration of xylometazoline HCl and fluticasone furoate appears to be beneficial in minimizing the long-term usage-associated congestion, edema, inflammatory cell infiltration, epithelial degeneration, and nasociliary loss in the rabbit model nasal mucosa. © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.