Epidemiology of organophosphate intoxication and predictors of intermediate syndrome

ÇOLAK Ş., ERDOĞAN M. Ö., Baydin A., Afacan M. A., Katı C., Duran L.

Turkish Journal of Medical Sciences, cilt.44, sa.2, ss.279-282, 2014 (SCI-Expanded, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3906/sag-1211-31
  • Dergi Adı: Turkish Journal of Medical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.279-282
  • Anahtar Kelimeler: Intoxication, organophosphate, hyperglycemia, intermediate syndrome, cholinesterase
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Aim: To evaluate the usefulness of plasma glucose and serum cholinesterase levels as predictors of organophosphate-induced intermediate syndrome. Materials and methods: Seventy-one organophosphate poisoning patients who were admitted to our emergency department during a 4-year period were evaluated retrospectively. Four patients were excluded from the study due to a lack of medical records. Categorical variables were analyzed using the chi-square test and nonparametric variables were analyzed using the Mann-Whitney U test. Results: Thirty-five (52.2%) patients were male and 32(47.8%) were female. Patients had a mean age of 39.4 ± 15.9 years and 70.1% of the patients were married. Oral intake (68.7%) was the most common method of intoxication, and attempted suicide (67.2%) was the most common cause. Te most common organophosphates were methamidophos (20.8%), dichlorvos (19.4%), parathion (7.5%), and methyl parathion (7.5%). Fifty-seven (85%) patients were treated in the emergency observation unit and 10 (15%) patients were admitted to the intensive care unit. Eleven (16%) patients developed intermediate syndrome and had significantly lower levels of serum cholinesterase (P < 0.01) and higher blood glucose levels (P = 0.037). Conclusion: Initial serum cholinesterase and glucose levels measured in the emergency department may be a useful marker in predicting organophosphate-induced intermediate syndrome. © TÜBİTAK.