Anticancer Effects of Urtica Dioica in Breast Cancer
Asian Pacific Journal of Cancer Prevention, cilt.23, sa.2, ss.673-681, 2022 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.31557/apjcp.2022.23.2.673
- Dergi Adı: Asian Pacific Journal of Cancer Prevention
- Derginin Tarandığı İndeksler: Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
- Sayfa Sayıları: ss.673-681
- Anahtar Kelimeler: Anticancer, Breast cancer, Cytotoxicity, In vitro, Urtica dioica
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The goal of this study is to look into the antiproliferative capabilities of Urtica Dioica (UD) on breast cancer. Methods: The cytotoxicity of UD extracts against breast cancer cell lines was investigated. Flow cytometry analyses were used to investigate in vitro apoptosis of breast cancer cells using Annexin V labeling. In vivo tests also performed. Results: UD showed cytotoxicity to three cancer cell lines. The number of Annexin-positive cells was higher in UD-treated cell lines than in untreated control cells. When compared to the untreated control group, the rats treated with UD had greater expressions of caspase 3, p53 protein, and TUNEL positive cells. When compared to the control group, Ki-67 expression was reduced in the treatment groups. In vivo tests revealed that, when compared to untreated rats, the mean tumor volume inhibition ratio in the UD group was 38 percent. Conclusion: These findings suggest that Urtica Dioica may have antitumoral properties in the treatment of breast cancer.