Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight
Expert Opinion on Drug Metabolism and Toxicology, cilt.17, sa.7, ss.823-840, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 17 Sayı: 7
- Basım Tarihi: 2021
- Doi Numarası: 10.1080/17425255.2021.1931682
- Dergi Adı: Expert Opinion on Drug Metabolism and Toxicology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
- Sayfa Sayıları: ss.823-840
- Anahtar Kelimeler: Hyaluronic acid, high-molecular-weight hyaluronic acid, absorption, pregnancy, recurrent miscarriage, preeclampsia, pre-term birth
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: For many years hyaluronic acid (HA) was mainly used for its hydrating properties. However, new applications have recently arisen, considering the biological properties of HA and its molecular weight. Clinical application of low molecular weight HA (LMW-HA) initially was supported by specific absorption data. The identification of high molecular weight HA (HMW-HA) absorption pathways and the knowledge of its physiological role allowed to evaluate its clinical application. Based on the immunomodulatory properties of HMW-HA and its physiological involvement as signaling molecule, pregnancy represents an interesting context of application. Area covered: This expert opinion includes in-vitro, in-vivo, ex-vivo and clinical studies on gestational models. It provides an overview of the physiological and the therapeutic role of HMW-HA in pregnancy starting from its metabolism. Indeed, HMW-HA is widely involved in several physiological processes as implantation, immune response, uterine quiescence and cervical remodeling, and therefore is an essential molecule for a successful pregnancy. Expert opinion: Available evidence suggests that HMW-HA administration can support physiological pregnancy, favoring blastocyst adhesion and development, preventing miscarriage and pre-term birth. For this reason, supplementation in pregnancy should be evaluated.