Combination of propofol and nasal sufentanil or intravenous midazolam for colonoscopy: A comparative study
Anaesthesiology Intensive Therapy, cilt.53, sa.2, ss.146-152, 2021 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.5114/ait.2021.106298
- Dergi Adı: Anaesthesiology Intensive Therapy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
- Sayfa Sayıları: ss.146-152
- Anahtar Kelimeler: propofol, sufentanil, midazolam, intranasal, colonoscopy
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: The aim of the study was to compare and evaluate the side effects (SEs) and sedation characteristics of synergistic sedation with doses of 0.25 μg kg-1or 0.5 μg kg-1intranasal (IN) sufentanil, and intravenous (IV) midazolam during propofol-based sedation in patients undergoing colonoscopy. Methods: This was a prospective, randomized, double-blind study. The patients were randomly allocated into one of 3 groups: Group I (n = 33)-sufentanil IN 0.5 μg kg-1group II (n = 33)-sufentanil IN 0.25 μg kg-1and group III (n = 33)-IN 0.9% NaCl (placebo) and IV 0.04 mg kg-1 midazolam. After 15 minutes, all patients received 0.5 mg kg-1propofol intravenously. Cardiorespiratory side effects and sedation characteristics were compared. Results: The propofol consumption in group III was significantly higher than in group I and II (P < 0.001). Spontaneous eye opening time was significantly longer in group III than in group I and II ( < 0.001). The patients in group III had significantly longer recovery times than patients in group I and II (P < 0.0001). Hypotension and bradycardia were not encountered during the study. The incidence of hypoxaemia was significantly greater in group III compared to other groups (P < 0.001). Pain control and endoscopist satisfaction was significantly better for group I and II than for group III (P < 0.001). Conclusions: Synergistic sedation can be achieved safely and effectively by the combination of propofol and IN sufentanil or IV midazolam for colonoscopy. However, IN sufentanil can be considered as a reasonable alternative to IV midazolam due to less respiratory depression, and better pain control and endoscopist satisfaction.