Comparison of the Use of Blue Dye Only and the Use of Blue Dye and Raiocolloid Together in Sentinel Lymph Node Detection in Early Stage Breast Cancer ERKEN EVRE MEME KANSERİNDE SENTİNEL LENF NODU TESPİTİNDE SADECE MAVİ BOYA KULLANIMI İLE MAVİ BOYA VE RADYOKOLLOİD BİRLİKTE KULLANIMININ KARŞILAŞTIRILMASI
Journal of Kirikkale University Faculty of Medicine, cilt.26, sa.2, ss.214-222, 2024 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 2
- Basım Tarihi: 2024
- Doi Numarası: 10.24938/kutfd.1476493
- Dergi Adı: Journal of Kirikkale University Faculty of Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.214-222
- Anahtar Kelimeler: blue dye, breast cancer, radiocolloid, Sentinel lymph node biopsy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: In the mid-1990s, sentinel lymph node biopsy began to be used in the evaluation of axillary lymph node status in breast cancer patients and has now become the procedure of choice for axillary staging in clinically axilla-negative breast cancer patients. In the detection of sentinel lymph node, only the blue dye method or only the radiocolloid material method and the combined method where both are used together are applied. Material and Methods: The files of patients who were operated on for breast cancer between 01/07/2013 and 01/07/2014 were examined retrospectively. Patients who underwent sentinal lymph node biopsy due to clinically axilla-negative early stage breast cancer were included in the study. Patients with clinically positive axilla, locally advanced and advanced stage breast cancer, and patients receiving neoadjuvant treatment were not included in the study. A total of 68 patients who underwent sentinel lymph node biopsy due to clinically axilla-negative early stage breast cancer were included in the study. The patients were divided into two groups: those whose sentinel lymph node biopsy was performed using the blue dye method and those whose combined method (blue dye + radiocolloid) was performed. There were 41 patients in the blue dye group and 27 patients in the combined group. The removed sentinel lymph node was evaluated by intraoperative frozen examination, and axillary lymph node dissection was performed in patients with metastases. Results: Sentinel lymph nodes were not found in 6 of 41 patients in the methylene blue group, and sentinal lymph nodes were detected at a rate of 85%. Metastasis was observed in the sentinel lymph nodes of ten patients and the positivity rate was found to be 24%. Sentinal nodes were found in all 27 patients in the combined group, and sentinel lymph nodes were detected in 100%. Sentinel lymph node metastasis was observed in ten patients and the positivity rate was found to be 37%. Conclusion: In this study, it was determined that the combined method was significantly superior to the blue dye method alone in preoperative sentinel lymph node detection in clinically axilla-negative early stage breast cancer.