The effects of ankaferd on liver regeneration after partial hepatectomy in rats Efectul administrärii de Ankaferd asupra regenerärii hepatocitare dupä hepatectomie partíala la soared
Chirurgia (Romania), cilt.116, sa.3, ss.347-353, 2021 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 116 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.21614/chirurgia.116.3.347
- Dergi Adı: Chirurgia (Romania)
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.347-353
- Anahtar Kelimeler: partial hepatectomy, rat model, Ankaferd, regeneration, cytoplasmic vacuolization
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: In this study, we aim at investigating the effect of post partial hepatectomy Ankaferd blood stopper (ABS) on liver regeneration in rats. Methods: Twenty-four rats were included in our study divided into three groups. (Group A = (Sham) 8 rats, Group B = (control) 8 rats, Group C = (experimental) 8 rats). Two-thirds hepatectomy was employed in all rats. Intraperitoneal 0.9% saline was administered to the rats in the control group, and intraperitoneal 1 ml Ankaferd was administered to the rats in the experimental group. The rats were sacrificed on the 7th day. Tissue samples were taken from the liver tissue for histopathological evaluation. Results: The number of mitosis and the cytoplasmic vacuolization/hdyropic degeneration scores were statistically different between the groups (Group A: 11.63 vs Group B: 17.00 vs Group C 8.88 (p:0.028) and Group A: 8.56 vs Group B: 16.63 vs Group C: 12.31 (p:0.034), respectively). The presence of binuclear hepatocytes score was p: 0.258 and disorganized distribution in cell proliferation in the parenchyma score was:0.076; There was no statistical difference between the groups. The number of mitosis was p:0116 for Group A-B, p:1.00 for Group A-C and p:0.017 for Group B-C Conclusions Positive results indicating an increase in liver regeneration due to Ankaferd were not obtained in our study.