Comparative efficacy of EMLA cream, lidocaine spray, and benzocaine condoms in treating lifelong premature ejaculation: a randomized clinical study
World Journal of Urology, cilt.43, sa.1, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.1007/s00345-025-06015-3
- Dergi Adı: World Journal of Urology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Gender Studies Database, MEDLINE
- Anahtar Kelimeler: Premature ejaculation, Local anesthetic, Intravaginal ejaculation latency, Lidocaine, Benzocaine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Premature ejaculation (PE) is the most common sexual dysfunction in men, negatively affecting quality of life and psychological well-being. Local anesthetic agents, such as lidocaine and benzocaine, which help manage PE by reducing glans penis sensitivity, are widely used in the treatment of PE. However, comparative data on the efficacy of different topical agents are limited. Objective: This study aims to evaluate and compare the effects of EMLA cream (lidocaine and prilocaine), lidocaine spray, and benzocaine condoms on intravaginal ejaculation latency time (IELT) in patients diagnosed with lifelong PE. Materials and methods: In this prospective study, 273 male patients who met ISSM criteria and presented to the andrology outpatient clinic were examined. Patients were randomized into three groups: 59 patients used EMLA cream, 126 patients used lidocaine spray, and 88 patients used benzocaine condoms. Data on age, BMI, duration of marriage, frequency of intercourse, and IELT (pre- and post-treatment) were collected. Results: IELT was significantly prolonged in all groups after treatment (p < 0.05). The highest IELT increase was observed in the lidocaine spray group, followed by the EMLA cream and benzocaine condom groups. Side effects were minimal and the lowest in the condom group. Conclusion: Lidocaine spray and EMLA cream significantly prolonged IELT compared to benzocaine condoms, demonstrating their short-term effectiveness in the management of PE. Further studies are needed to evaluate the long-term efficacy and patient satisfaction of these treatments.