The etiology and clinical follow-up of patients with acute viral hepatitis in an adult population: A prospective multicenter study Erişkin Popülasyonda Akut Viral Hepatitli Hastaların Etiyolojisi ve Klinik Takibi: Prospektif Çok Merkezli Bir Çalışma
Viral Hepatitis Journal, cilt.27, sa.2, ss.36-41, 2021 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.4274/vhd.galenos.2021.2021-3-1
- Dergi Adı: Viral Hepatitis Journal
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.36-41
- Anahtar Kelimeler: Acute viral hepatitis, hepatitis A virus, hepatitis B virus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: To assess the causes, patient characteristics, clinical follow-up of acute viral hepatitis in adults. Materials and Methods: This prospective study is conducted in acute viral hepatitis patients from different centers across Turkey. Results: From 8 hospitals in 6 provinces, 75 patients (59 males/79%) between 20 and 69 years of age (mean age: 34.65±11.82 years) with proven viral hepatitis were included into the study. There were 54 (72%) patients with acute hepatitis B virus (HBV), 19 (25%) with acute hepatitis A virus (HAV), 1 (1.3%) with acute Epstein-Barr virus, and 1 (1.3%) with acute cytomegalovirus infection. Patients between 23-33 years of age represented that greater majority of the patient group (41.3%), followed by those between 34 and 43 years of age (20%). The mean age among acute HAV patients, i.e. 27±5.7 years (20-38 y) was significantly (p<0.001) lower than the mean age of 37.6±12.2 years (20-69 y) acute HBV group. Of 51 isolated acute HBV patients: 44 (86%) developed immunity during the follow up [anti-hepatitis B core antibody immunoglobulin G (anti-HBc IgG) and anti-HBs positivity], while isolated anti-HBc IgG positivity persisted in 4 patients (8%) and 3 patients (%6) were considered as chronic HBV infection due to persistence of hepatitis B surface antigen positivity beyond 6 months. Conclusion: Acute HBV infection remains an important health problem in our country, and horizontal and sexual transmission became the predominant routes of transmission for HBV. Also, acute HAV infection is a prevalent condition in young adults.