A case of surgically treated bilateral metachronous malignant pleural mesothelioma
Turkish Journal of Thoracic and Cardiovascular Surgery, cilt.27, sa.1, ss.121-124, 2019 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 1
- Basım Tarihi: 2019
- Doi Numarası: 10.5606/tgkdc.dergisi.2019.16162
- Dergi Adı: Turkish Journal of Thoracic and Cardiovascular Surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.121-124
- Anahtar Kelimeler: Asbestosis, malign pleural mesothelioma, pleural tumor, surgery
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this article, we present a 59-year-old male patient who was admitted to our hospital with right pleural effusion and right-sided chest pain and diagnosed as malignant pleural mesothelioma with thoracentesis and pleural biopsy. After the patient was determined to be operable, right parietal pleurectomy + pericardial resection + diaphragmatic resection were performed and four cycles of cisplatin and pemetrexed combination as adjuvant treatment were added. The patient was followed-up without any problem for three and a half years. At this time, left-sided chest pain and leftsided effusion were noticed. Tumor was negative in thoracentesis and pleural biopsy. Then, video-assisted thoracoscopic surgery was applied, which resulted in Stage 1a malignant pleural mesothelioma. Thoracoscopic parietal pleurectomy was performed with success. Four cycles of pemetrexed single-agent therapy was performed as an adjuvant treatment. The patient died of chronic obstructive pulmonary disease and heart failure in 57th month of the first and 21st month of the second operation while he was tumor free. To the best of our knowledge, this case is the first operated bilateral metachronous primary malignant pleural mesothelioma in the literature. Bu yazida, hastanemize sağ plevral efüzyon ve sağ tarafli göğüs ağrisi ile kabul edilen ve torasentez ve plevral biyopsi ile malign plevral mezotelyoma tanisi konulan 59 yaşinda bir erkek hasta sunuldu. Hastanin ameliyat edilebilir olduğunun belirlenmesini takiben, sağ parietal plörektomi + perikardiyal rezeksiyon + diyafragma rezeksiyonu uygulandi ve adjuvan tedavi olarak dört siklus sisplatin ve pemetreksed kombinasyonu eklendi. Hasta üç buçuk yil boyunca herhangi bir problem olmaksizin takip edildi. Bu dönemde, sol tarafli göğüs ağrisi ve sol tarafli efüzyon fark edildi. Torasentez ve plevral biyopside tümör negatif idi. Sonra, evre 1a malign plevral mezotelyoma ile sonuçlanan video yardimli torakoskopik cerrahi gerçekleştirildi. Torakoskopik parietal plörektomi başariyla uygulandi. Adjuvan tedavi olarak dört siklus pemetreksed tek ajan terapisi uygulandi. Hasta tümörsüzken birinci ameliyatin 57. ve ikincisinin 21. ayinda kronik obstrüktif akciğer hastaliği ve kalp yetmezliği nedeniyle öldü. Bildiğimiz kadariyla, bu olgu literatürdeki ilk ameliyat edilmiş iki tarafli metakron primer malign plevral mezotelyomadir.