The Prognostic Impact of Acute Kidney Injury in Patients with Moderate and Low-Risk Pulmonary Embolism Orta ve Düşük Riskli Pulmoner Emboli Hastalarında Akut Böbrek Hasarının Prognostik Etkisi

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Eraslan B. Z., Oruç M., CÖMERT S.

Medical Journal of Bakirkoy, cilt.21, sa.4, ss.368-373, 2025 (ESCI, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2025
  • Doi Numarası: 10.4274/bmj.galenos.2025.2024.3-5
  • Dergi Adı: Medical Journal of Bakirkoy
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.368-373
  • Anahtar Kelimeler: Acute kidney injury, pulmonary embolism, mortality
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objective: This study aimed to evaluate the incidence of acute kidney injury (AKI) and its impact on prognosis in patients diagnosed with acute pulmonary embolism (PE). Methods: Patients hospitalized with a diagnosis of acute PE between January 2018 and March 2023 were retrospectively reviewed. Demographic data; comorbidities; risk factors such as atrial fibrillation, malignancy, immobilization, history of surgery, fracture, and deep vein thrombosis (DVT); biochemical parameters; and 30-day mortality were recorded. AKI was diagnosed using the kidney disease: improving global outcomes criteria. Results: AKI was identified in 11.8% of the 186 patients. Compared with those without AKI, patients with AKI were older (p=0.024) and had a higher prevalence of diabetes, chronic kidney disease, atrial fibrillation, and immobilization (p=0.035, 0.001, 0.027, and <0.001, respectively). In the AKI group, serum creatinine and troponin levels were higher, while estimated glomerular filtration rate and serum albumin levels were lower. In the mortality group, comorbidities such as diabetes mellitus, malignancy, immobilization, concomitant DVT, and a simplified pulmonary embolism severity index score ≥1 were observed more frequently. However, there was no significant difference in mortality between patients with and without AKI at admission or during hospitalization (p=0.079). Conclusion: Among patients with acute PE, AKI present at admission does not independently affect 30-day mortality. However, the occurrence of AKI at admission or during hospitalization was associated with a non-significant trend toward increased mortality (p=0.079).