Effect of bevacizumab on postoperative adhesion formation in a rat uterine horn adhesion model and the correlation with vascular endothelial growth factor and Ki-67 immunopositivity

MORALOĞLU TEKİN, Özlem; Işik, Hatice; Kiliç, Sevtap; Şahin, Ulaş; Çaydere, Muzaffer; Üstün, Hüseyin; Batoglu, Sertaç

doi:10.1016/j.fertnstert.2011.02.005

Effect of bevacizumab on postoperative adhesion formation in a rat uterine horn adhesion model and the correlation with vascular endothelial growth factor and Ki-67 immunopositivity

MORALOĞLU TEKİN Ö., Işik H., Kiliç S., Şahin U., Çaydere M., Üstün H., ...Daha Fazla

Fertility and Sterility, cilt.95, sa.8, ss.2638-2641, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 95 Sayı: 8
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.fertnstert.2011.02.005
Dergi Adı: Fertility and Sterility
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2638-2641
Anahtar Kelimeler: Bevacizumab, experimental study, peritoneal adhesion, vascular endothelial growth factor
Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

We investigated whether adhesion formation is prevented by the inhibition of angiogenesis in a rat uterine horn adhesion model. A single-dose of bevacizumab was effective in preventing postoperative intraperitoneal adhesion formation among 30 Wistar albino rats that underwent serosal injury by use of a standard technique after laparotomy with intraperitoneal bevacizumab. © 2011 by American Society for Reproductive Medicine.