Pituitary adenoma presenting with non-puerperal mastitis during pregnancy
Turkiye Klinikleri Journal of Medical Sciences, cilt.27, sa.2, ss.304-307, 2007 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 2
- Basım Tarihi: 2007
- Dergi Adı: Turkiye Klinikleri Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.304-307
- Anahtar Kelimeler: mastitis, prolactinoma
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Gigantomastia is a rare condition of excessive enlargement of the breasts during pregnancy. In most cases, gigantomastia is caused by an excess of circulating hormones or by the hypersensitivity oi mammary tissue to normal hormone stimulation. In this case, we report a nonpuerperal mastitis case complicated with gigantomastia secondary to an incidentally detected pituitary microadenoma. The patient responded well to bromocriptine treatment. Copyright © 2007 by Turkiye Klinikleri. Indications:1 patient with non puerperal mastitis, gigantomastia of pregnancy and pituitary microadenoma. Patients:1 patient, a woman aged 27 years, treated as inpatient and outpatient. Duration of follow up was 1 month. TypeofStudy:Parlodel was effective in a pregnant patient with non-puerperal mastitis, gigantomastia of pregnancy and pituitary microadenoma. Case report. DosageDuration:2.5 mg bid (=5 mg daily). Duration: 1 month; therapy continues at time of report. Results:The patient started Parlodel therapy; miscarriage occurred 1 week later. Resolution of the breast pathology started at this time. The patient was discharged 1 week later, still taking Parlodel. After 1 month, breast pathology had completely resolved and serum prolactin had fallen into the normal range (28 ng/ml). MRI scan showed tumor shrinkage; no mass was visible. The patient was advised to continue Parlodel therapy for 1 year and to avoid pregnancy during this time. AdverseEffects:1 patient had spontaneous abortion. AuthorsConclusions:The patient responded well to bromocriptine and serum PRL [prolactin] level returned to normal in a very short period. Unfortunately, the gestation terminated with spontaneous abortion 1 week after the initiation of bromocriptine, and we are not sure whether the reason of abortion is bromocriptine treatment or not. Another interesting finding was that the patient had experienced this disease only during her fourth gestation although the previous three gestations similarly ended with spontaneous abortions. FreeText:The patient presented at 19 weeks of gestation with painful enlargement of the breasts which had not responded to antibiotics and anti-inflammatory agents. Serum prolactin was elevated at >200 ng/ml (normal range 1.2 to 30 ng/ml). MRI scan of the brain showed a pituitary microadenoma. Tests: serum prolactin, tumor size on MRI scan of brain.