TRIGLYCERIDE GLUCOSE INDEX IS ASSOCIATED WITH SUBCLINICAL ATHEROSCLEROSIS AND SUBCLINICAL MYOCARDIAL DYSFUNCTION IN PATIENTS WITH NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS ИНДЕКС ТРИГЛИЦЕРИДЫ-ГЛЮКОЗА АССОЦИИРОВАН С СУБКЛИНИЧЕСКИМ АТЕРОСКЛЕРОЗОМ И СУБКЛИНИЧЕСКОЙ ДИСФУНКЦИЕЙ МИОКАРДА У ПАЦИЕНТОВ С ВПЕРВЫЕ ВЫЯВЛЕННЫМ САХАРНЫМ ДИАБЕТОМ 2 ТИПА
Diabetes Mellitus, cilt.27, sa.3, ss.224-232, 2024 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 3
- Basım Tarihi: 2024
- Doi Numarası: 10.14341/dm13073
- Dergi Adı: Diabetes Mellitus
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.224-232
- Anahtar Kelimeler: type 2 diabetes, triglyceride glucose index, subclinical atherosclerosis, myocardial functions
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
BACKGROUND: Previous studies have shown that, the triglyceride glucose index (TyG index) is related with the development of cardiovascular disease. AIM: Our novel study aimed to determine whether the TyG index measured at the time of diagnosis conducted on newly diagnosed type 2 diabetic individuals and the relationship between TyG index and carotid intima media thickness, as well as both myocardial functions and epicardial adipose tissue was investigated. MATERIALS AND METHODS: The study included 105 individuals (58 F, 47 M; mean age 50.4±9.8 years) newly diagnosed with T2DM and 51 healthy subjects (30 females, 21 males, mean age 49.8±8.9 years) without any chronic disease as the control group. In addition to laboratory parameters, transthoracic echocardiography carotid intima-media thickness with linear vascular probe were examined in all individuals. RESULTS: TyG index was significantly higher in newly diagnosed type 2 diabetic individuals compared to the controls. There was a positive correlation between the TyG index and carotid intima-media thickness, epicardial fat thickness, HbA1c, Homa-IR, body surface area, waist circumference, hip circumference, body mass index and CRP. When diastolic functions were considered, there was a negative correlation with E/A and a positive correlation with E/e’ septal. TyG index was also negatively correlated with EF. Regression analysis revealed that age and TyG index were associated with an increase in carotid IMT thickness. CONCLUSION: TyG index measured at the time of diagnosis in newly diagnosed type 2 diabetic patients is also associated with subclinical atherosclerosis, deterioration in left ventricular systolic and diastolic functions.