Predictors of mortality in Staphylococcus aureus infections: The role of C-reactive protein, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio
Journal of International Medical Research, cilt.53, sa.8, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 8
- Basım Tarihi: 2025
- Doi Numarası: 10.1177/03000605251363105
- Dergi Adı: Journal of International Medical Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
- Anahtar Kelimeler: Staphylococcus aureus, C-reactive protein, systemic inflammation index, mortality, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Staphylococcus aureus causes infections ranging from mild skin conditions to life-threatening diseases such as endocarditis. The incidence of S. aureus infections is increasing due to the rise in invasive procedures and immunosuppression. Inflammatory markers such as C-reactive protein level, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio are useful for monitoring disease severity. This study aimed to identify the clinical and laboratory predictors of mortality in patients with S. aureus infections. Methods: This retrospective observational study included patients aged >18 years with S. aureus growth who were treated at a tertiary hospital between 1 November 2013 and 1 February 2022. Infections were classified as pneumonia or infections of the bloodstream, bone and joint, and skin and soft tissue. Results: Univariate analysis revealed that age >73 years, emergency department admission, and methicillin resistance were significant mortality risk factors. Multivariate analysis showed that age >73 years, pneumonia, and C-reactive protein level >86 mg/L increased the mortality rate by 3.5-, 7.6-, and 4.4-fold, respectively. Conclusion: C-reactive protein level, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio are accessible, cost-effective markers that aid in predicting mortality. Integrating these biomarkers with clinical parameters such as advanced age and pneumonia can improve early risk stratification in patients with S. aureus infections.