Relationship between serum tumor necrosis factor-alpha levels and insulin resistance in patients with chronic renal failure Kronik böbrek yetersizliǧi olan hastalarda serum tümör nekroz faktörü-alfa düzeyleri ile insülin direnci ilişkisi
Turkiye Klinikleri Journal of Medical Sciences, cilt.32, sa.1, ss.157-161, 2012 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2012
- Doi Numarası: 10.5336/medsci.2011-23421
- Dergi Adı: Turkiye Klinikleri Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.157-161
- Anahtar Kelimeler: Insulin resistance, renal insufficiency, chronic, tumor necrosis factor-alpha
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Chronic renal failure is a chronic microinflammatory process of cytokine dysregulation and increased insulin resistance is a known concept in these patients. Tumor necro-sis factor (TNF)-a is a proinflammatory cytokine and has been shown to increase in chronic renal failure patients in some studies. We planned this study to investigate TNF-α levels, insulin resis-tance values and interrelations in chronic renal failure patients. Material and Methods: A total of 60 subjects of whom 30 had chronic renal failure (15 females-group 1) and 30 were healthy con-trols (16 females-group 2) were included in the study. Serum creatinine, glomerular filtration rate levels, TNF-α, fasting plasma glucose, fasting insulin levels were studied and HOMA-IR was calcu-lated. Results: Mean values of glomerular filtration rate were detected as follows; group 1: 42.05 ± 24.60 ml/min and group 2: 106.67 ± 17.10 ml/min, TNF-α values were found as group1:57.65 ± 42.2 pg/ml and group 2:18.25 ± 7.90 pg/ml and HOMA-IR values were found as group 1:3.71 ± 2.56 and group 2: 2.37 ± 1.45. When HOMA-IR and TNF-α values of group 1 and 2 were compared respec-tively, a statistically significant difference was detected (p< 0.01) (p< 0.001). However a negative or positive relationship was not detected in bivariate correlation of HOMA-IR and TNF-α (r= 0.091, p= 0.634). TNF-α was found to be an independent variable for chronic kidney disease in regressi-on analysis (p= 0.010). Conclusion: In this study, insulin resistance was present in subjects with chronic renal failure and level of TNF-α in circulation was higher compared to controls without chronic renal failure. However, TNF-α did not have an influence on insulin resistance. © 2012 by Türkiye Klinikleri.