Glutathione and Chronic Hepatitis B Virus Infection Hepatit B Virus Enfeksiyonu ve Glutatyon
Genel Tip Dergisi, cilt.31, sa.3, ss.239-242, 2021 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.54005/geneltip.996762
- Dergi Adı: Genel Tip Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.239-242
- Anahtar Kelimeler: glutathione, Hepatitis B virus infection, oxidative stress
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: In this study, serum levels of antioxidant glutathione which can be used to follow of liver inflammation and disease progression and in treatment to prevent progressive liver damage and chronic liver disease and complications in patients with hepatitis B virus infection, were evaluated. Material and Methods: The study included 55 patients with hepatitis B virus infection, normal ALT levels, HBV DNA Neg-<104 c / ml, between the ages of 18-69 and 40 healthy controls, without any chronic disease or acute hepatitis. Serum GSH levels were determined by ELISA (Enzyme-Linked Immunosorbent Assay) method (R&D Systems, Minneapolis, MN, USA). Results: Of the hepatitis B virus infected cases, 29 were female and 26 were male (age range 43.75 ± 4.33), 17 of the control group were female and 23 were male (age range 29.31 ± 1.59). No statistically significant difference was found between the serum GSH level and age and gender among the cases with hepatitis B virus infection (p: 0.252, p: 0.353, respectively). Glutathione serum levels in hepatitis B virus infection were lower than control group and this was statistically significant (117.47±3.12, 151.18±1.93 ng/mL, respectively, p:0.001). There was no statistically significant difference between biochemical parameters and glutathione in patients with hepatitis B virus infection (p> 0.05). Conculusion: Oxidative stress is important in the development and progression of liver damage Glutathione can be used in patients with hepatitis B infection, to follow liver inflammation and disease progression. In addition, it can be used in treatment to prevent the occurrence of chronic liver disease and complications by suppressing inflammation with its antioxidant effect.