The Use of Propofol to Induce Anesthesia can Mitigate the Oxidative Stress Created by Laparoscopic Cholecystectomy, but not Thiopental Anestezi Indüksiyonu için Propofol Kullanımı Laparoskopik Kolesistektominin Yarattığı Oksidatif Stresi Hafifletebilir Ancak Tiyopental Bunu Azaltamaz
Genel Tip Dergisi, cilt.34, sa.4, ss.554-558, 2024 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 4
- Basım Tarihi: 2024
- Doi Numarası: 10.54005/geneltip.1473649
- Dergi Adı: Genel Tip Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.554-558
- Anahtar Kelimeler: Antioxidants, Disulfides, Laparoscopic cholecystectomy, Oxidative stress, Propofol, Thiol, Thiopental
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: Laparoscopic cholecystectomy is one of the treatment methods employed in symptomatic cholelithiasis cases, and pneumoperitoneum has been shown to increase oxidative stress. Our aim is to compare propofol and thiopental in terms of their effects on oxidative stress parameters in laparoscopic cholecystectomy cases. Materials and Methods: After obtaining Ethics Committee permission, patients who underwent laparoscopic cholecystectomy were divided into thiopental and propofol groups according to the agent used for anesthesia induction in the randomized and prospective study. Serum oxidative stress parameters levels were measured in all patients twice before induction of general anesthesia and at the 30th minute postoperatively. Results: When comparing the preoperative period with the postoperative period, total antioxidant status (TAS) levels increased statistically significantly in the propofol group (preoperatively 1.21±0.21 mmolH2O2/L, postoperatively 1.31±0.18 mmolH2O2/L, p<0.001) compared to the thiopental group (preoperatively 1.23±0.14 mmolH2O2/L, postoperatively 1.27±0.14 mmolH2O2/L, p=0.055). arylesterase (ARES), serum native thiol, total thiol, and disulfide levels decreased statistically significantly in both groups. While Paraoxonase-1 (PON1) level did not change in the propofol group, it decreased in the thiopental group. Conclusion: We concluded that propofol had a significantly greater oxidative stress reduction effect than thiopental. By increasing the TAS levels, propofol may have a more positive effect on oxidative stress than thiopental. However, neither propofol nor thiopental have oxidative stress-reducing effects on other oxidative stress parameters.