Cerebellar aspergillosis: Case report and literature review
Neurosurgery, cilt.50, sa.4, ss.874-877, 2002 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 4
- Basım Tarihi: 2002
- Doi Numarası: 10.1097/00006123-200204000-00036
- Dergi Adı: Neurosurgery
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.874-877
- Anahtar Kelimeler: aspergillosis, breast, cancer, cerebellar, treatment
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE AND IMPORTANCE: An unusual, but not unique, case of cerebellar aspergillosis associated with autologous peripheral blood stem cell transplantation for breast cancer is presented. CLINICAL PRESENTATION: A 45-year-old woman with breast cancer underwent chemotherapy and radiotherapy as well as autologous peripheral blood stem cell transplantation. She developed a cerebellar aspergillosis abscess that was treated successfully with two surgical resections. INTERVENTION: After removal of pus and the abscess wall, the patient received local application of amphotericin B (AmB). She received AmB 1 mg/kg/d for 3 months and itraconazole 100 mg/kg/d for 1 year. After 3 months of AmB treatment, magnetic resonance imaging revealed that disease had not recurred. CONCLUSION: In cases of central nervous system aspergillosis, to increase the therapeutic efficiency, AmB can also be applied to the abscess cavity. Computed tomographic and contrast-enhanced magnetic resonance imaging scans play an important role in establishing early diagnosis in high-risk, immunocompromised patients.