Serum SIRT1 level is higher in male patient with isolated hypogonadotropic hypogonadism: The first study in human El nivel de serum SIRT1 es mayor en pacientes masculinos con hipogonadismo hipogonadotrópico: el primer estudio en humanos
Revista Internacional de Andrologia, cilt.15, sa.1, ss.2-7, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 1
- Basım Tarihi: 2017
- Doi Numarası: 10.1016/j.androl.2016.06.003
- Dergi Adı: Revista Internacional de Andrologia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2-7
- Anahtar Kelimeler: Hypogonadotropic hypogonadism, Sirtuin1, Insulin resistance
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective Our aim is to compare the serum SIRT1 levels between patients with hypogonadotropic hypogonadism and healthy subjects. Material and method Twenty-five male patients diagnosed with isolated hypogonadotropic hypogonadism (IHH) and thirty healthy male as a control group were included in the study. Serum SIRT1, hormone levels and biochemical parameters, age, body mass index and insulin resistance were compared in both groups. Results Mean serum SIRT1 levels in patient and control group were 20.1 ± 11.7 ng/ml and 12.8 ± 7.1 ng/ml, respectively. Difference between both groups was statistically significant (p = 0.02). The difference of Homeostasis Model Assessment-Insulin Resistance index (HOMA-IR) between two groups was also statistically significant. Patient group had more insulin resistance than the control group and it was statistically significant (mean HOMA-IR 2.66 ± 1.57 vs. 1.38 ± 0.43; p = 0.002). Conclusions This is the first human study that investigates SIRT1 levels and its relation with metabolic and hormonal parameters. We demonstrated that serum SIRT1 levels in patients with IHH were significantly higher than controls, and there is a negative correlation between testosterone and SIRT1 levels. The reason for elevated SIRT1 levels may be a compensation mechanism against both hypogonadotropic hypogonadism and insulin resistance. To understand the relation between SIRT1 and androgen deficiency, further large-scale randomized control studies are needed.