THE EFFECTS OF OMEGA-3 FATTY ACIDS ON ANTIOXIDANT ENZYME ACTIVITIES AND NITRIC OXIDE LEVELS IN THE CEREBRAL CORTEX OF RATS TREATED ETHANOL ВЛИЯНИЕ ω-3 ЖИРНЫХ КИСЛОТ НА АКТИВНОСТЬ АНТИОКСИДАНТНЫХ ФЕРМЕНТОВ И УРОВЕНЬ ОКСИДА АЗОТА В КОРЕ ГОЛОВНОГО МОЗГА КРЫС, ПОДВЕРГНУТЫХ ВОЗДЕЙСТВИЮ ЭТАНОЛОМ
Biomeditsinskaya Khimiya, cilt.70, sa.2, ss.83-88, 2024 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 70 Sayı: 2
- Basım Tarihi: 2024
- Doi Numarası: 10.18097/pbmc20247002083
- Dergi Adı: Biomeditsinskaya Khimiya
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.83-88
- Anahtar Kelimeler: alcohol withdrawal, brain, superoxide dismutase
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The toxic effect of ethanol on the cerebral cortex and protective effects of omega-3 fatty acids against this neurotoxicity were investigated. Twenty eight male Wistar-albino rats were divided into 4 groups. Rats of the ethanol and ethanol withdrawal groups were treated with ethanol (6 g/kg/day) for 15 days. Animals of the ethanol+omega-3 group received omega-3 fatty acids (400 mg/kg daily) and ethanol. In rats of the ethanol group SOD activity was lower than in animals of the control group. In rats treated with omega-3 fatty acids along with ethanol, SOD activity increased. GSH-Px activity and MDA levels in animals of all groups were similar. In ethanol treated rats NO levels significantly decreased as compared to the animals of the control group (6.45±0.24 nmol/g vs 11.05±0.53 nmol/g, p<0.001). In rats receiving ethanol+omega-3, there was a significant increase in the NO level as compared to animals of the ethanol group (13.12±0.37 nmol/g vs 6.45±0.24 nmol/g, p<0.001). Thus, ethanol administration leads to oxidative damage and a decrease in the NO level. Omega-3 fatty acids have a protective role against ethanol induced oxidative damage and normalize the NO level.