Association of a polymorphism of the ecNOS gene with myocardial infarction in a subgroup of Turkish MI patients
Clinical Genetics, cilt.61, sa.1, ss.66-70, 2002 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 61 Sayı: 1
- Basım Tarihi: 2002
- Doi Numarası: 10.1034/j.1399-0004.2002.610113.x
- Dergi Adı: Clinical Genetics
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.66-70
- Anahtar Kelimeler: 3, 297NOS gene, myocardial infarction, polymorphism
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this study we examined a possible association between a 27 base pair (bp)-repeat polymorphism in intron 4 of the ecNOS gene and myocardial infarction (MI) in a subgroup of the Turkish population. We compared MI and control groups for the frequencies of the ecNOS alleles and their genotypes. The frequency of the ecNOS 4a/a and 4a/b genotypes was found to be significantly higher in the MI group than in the control group. Interestingly, the frequency of the ecNOS 4a/b polymorphism was found to be significantly higher in the selected MI group (patients with no known secondary risk factors) than in the control and non-selected MI group. We found that the patients with MI had the frequency of the a/a genotype 4.3%, of the a/b genotype 26.6% and the b/b genotype 69.1%. The controls, however, showed only 0.6% for a/a, 18.0% for a/b and 81.4% for the b/b genotype (P < 0.001; X2 = 13.626). In this study, we show that myocardial infarction is associated with one subtype of ecNOS gene polymorphism.