A mathematical model for pattern of change in β-cell reserve and factors affecting residual reserve within the first 2 years of Type 1 diabetes
Journal of Endocrinological Investigation, cilt.25, sa.11, ss.987-992, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 11
- Basım Tarihi: 2002
- Doi Numarası: 10.1007/bf03344073
- Dergi Adı: Journal of Endocrinological Investigation
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.987-992
- Anahtar Kelimeler: beta-cell reserve, glucagon, Type 1 diabetes, stimulated C-peptide, mathematical model
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The aim of this study was to investigate the effects of age, duration of diabetes, sex and ICA (Islet cell cytoplasmic antibody) on β-cell reserves and to develop a model within the first 2 years of Type 1 diabetes. Beta-cell reserve is evaluated as fasting (FCp) and 1 mg IV glucagon stimulated C-peptide (SCp) levels in 58 Type 1 diabetics and in 12 normoglycemic subjects. Patients were divided into 3 groups according to duration of diabetes: Group I (2.5±0.3 weeks), Group II (13.4±1.2 months) and Group III (24.2±1.8 months). FCp/SCp level in nmol/l (mean±SE) were as follows. Group I: 0.21±0.02/0.38±0.04, Group II: 0.15±0.01/0.27±0.02, Group III: 0.07±0.01/0.11±0.02, Control group: 0.42±0.09/1.29±0.13. The scatter plots of C-peptide levels vs time in all the diabetic patients fitted in to a 4th-order polynomial regression (R: 0.96-0.98). Age was strongly correlated with FCp (rs: 0.46, p<0.05) and ICA positivity affected Cp-levels negatively (p>0.05). In conclusion, as the duration of diabetes increases, response time to glucagon prolongs and amplitude of it shortens. Duration of diabetes of less than 2 weeks, feminity, puberty and ICA positivity affect β-cell reserve negatively, conversely, masculinity, post-puberty, older age and ICA negativity affect the reserve positively. The dynamics of C-peptide response to glucagon follow a mathematical model and Type 1 diabetes causes a decrease not only in the amplitude of the response but also in the duration of the response. ©2002, Editrice Kurtis.