Intestinal blood flow by Doppler ultrasound: The impact of clarithromycin treatment for feeding intolerance in preterm neonates
Journal of Maternal-Fetal and Neonatal Medicine, cilt.29, sa.11, ss.1853-1856, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 11
- Basım Tarihi: 2016
- Doi Numarası: 10.3109/14767058.2015.1066327
- Dergi Adı: Journal of Maternal-Fetal and Neonatal Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1853-1856
- Anahtar Kelimeler: Clarithromycin, feeding intolerance, intestinal blood flow, neonate, preterm
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To compare the blood flow velocities of superior mesenteric artery (SMA) before versus after clarithromycin treatment for feeding intolerance in very low-birth weight infants. Methods: A prospective study was conducted in a group of infant <1500 g with feeding intolerance who received clarithromycin 7.5 mg/kg/dose bid. Before and at the third day of the clarithromycin therapy, SMA blood flow velocity was measured with Doppler ultrasound. Results: SMA peak systolic velocity (PSV) and mean systolic velocity (MV) on the third day of the treatment was found significantly higher than the initial measurement (p = 0.013 and p = 0.027, respectively). End diastolic velocity of the SMA did not change with clarithromycin therapy (p = 0.113). There were no significant changes about pulsatility and resistive index of SMA with regard to clarithromycin therapy. Conclusion: Clarithromycin effects the splanchnic circulation. The rise in PSV and MV in SMA is remarkable. These results suggest that the splanchnic blood flow increases significantly after clarithromycin usage.