Association of C-Reactive Protein-to-Albumin Ratio With the Presence and Progression of Abdominal Aortic Aneurysm
Angiology, cilt.72, sa.2, ss.153-158, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 72 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.1177/0003319720954084
- Dergi Adı: Angiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE
- Sayfa Sayıları: ss.153-158
- Anahtar Kelimeler: inflammation, abdominal aortic aneurysm, C-reactive protein-to-albumin ratio
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aortic dilatation due to inflammation may lead to an increase in C-reactive protein (CRP) levels. We investigated the possible relationship between CRP-to-albumin ratio (CAR) and presence and progression of abdominal aortic aneurysms (AAAs). The study included 150 patients previously diagnosed with AAA (diameter 40-54 mm) and 100 normal controls. Clinical and laboratory parameters and maximal cross-sectional AAA diameters (measured by computed tomography angiography) were obtained from all participants at baseline assessment as well as after 1 year for those with an AAA. The patients with AAA had significantly higher serum CAR compared with controls at baseline (P <.001). Increased serum CAR was found to be an independent predictor of the presence of AAA (odds ratio: 3.162, 95% CI: 1.690-5.126, P =.001) after multivariate logistic regression analysis. There was a significant increase in aortic diameter and CAR after 1 year in the patients with AAA (P <.001; P =.003); a significant correlation was found between changes in the diameter of AAAs and CAR (r = 0.414; P =.005). Serum CAR may be useful as an inflammatory biomarker for the presence and progression of AAA.