Current status of pediatric formulations for chronic and acute children’ diseases: Applications and future perspectives Kronik ve akut çocuk hastalıkları için pediatrik formülasyonların mevcut durumu: Uygulamalar ve gelecekteki bakış açıları
Medeniyet Medical Journal, cilt.36, sa.2, ss.152-162, 2021 (Scopus, TRDizin)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 36 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.5222/mmj.2021.78476
- Dergi Adı: Medeniyet Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.152-162
- Anahtar Kelimeler: Pediatric diseases, pediatric formulations, drug delivery systems, infants, children, pharmaceutical technology
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Infants and other children can be affected by various acute, chronic and many of them rare ill-nesses. Developing drugs for children is very challenging since they cannot intake tablets or hard oral solid dosage forms. Besides, most of the prescribed pediatric medications are unlicensed. The biggest issue that clinicians have to solve is that dosing in children is not based on weight or surface area of the body, as it happened in adults but is related to age variations in drug absorption, distribution, metabolism, and elimination. Thus, for pediatric patients, various the-rapeutic approaches have been proposed so as to develop suitable formulations such as liquid dosage forms, flexible capsules, milk-based products, etc. In addition, the administration of current pharmaceutical products to children might lead to some serious side effects which can also happen in adults but with a lower risk. Especially, infants are at high risk of getting poisoned by taking drugs used for adults. Moreover, children are very sensitive to the taste and smell of some pharmaceutical vehicles and can resist to intake them and this situation leads parents to search for tasteless and odorless medications. In this study, the current formulations for various diseases intended to be used in pediatric patients as well as various chronic and acute diseases of childhood are summarized. Authors believe that this review can help professionals who want to work with pediatric formulations to design more efficient and child-friendly drug delivery systems.