Evaluation of Clinical and Laboratory Features of Rhinovirus Infections in Children
Journal of Pediatric Infectious Diseases, cilt.19, sa.3, ss.162-170, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 3
- Basım Tarihi: 2024
- Doi Numarası: 10.1055/s-0044-1786378
- Dergi Adı: Journal of Pediatric Infectious Diseases
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.162-170
- Anahtar Kelimeler: rhinovirus, mechanical ventilation, asthma, chronic lung disease, immunodeficiency, neurometabolic disease
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Our aim in this study was to evaluate the clinical characteristics of patients afflicted with rhinovirus (RV) infections, compare their laboratory findings with a healthy population, determine the features of the clinical course of the illness in individuals with a chronic disease, and set out the risk factors involved in the need for mechanical ventilation (MV). Methods: The study was conducted on 318 pediatric patients aged 0 to 18 years diagnosed with RV infection. Patients were divided into two main groups, those with and without a chronic disease. The group with chronic disease was divided into four subgroups. Children with RV were compared with a control group of 231 healthy children. Results: The most common symptoms and signs were wheeze (65.4%), cough (65.1%), and tachypnea (50.3%). Compared with the healthy population, RV-positive patients showed significant increases in their white blood cell (WBC), neutrophil, and platelet counts, and in their delta neutrophil index and C-reactive protein values (all p < 0.001). The most important risk factors in terms of the need for MV were elevated WBC (odds ratio [OR] = 1.404, 95% confidence interval [CI]: 1.059-1.862), chronic lung disease (CLD) (OR = 5.196, 95% CI: 2.296-11.762), reticular involvement (OR = 3.132, 95% CI: 1.259-7.793), and lobar involvement (OR = 10.575, 95% CI: 13.434-32.564). Conclusion: It is of vital importance that individuals with asthma and CLD are closely monitored and protected during RV seasonal periods as they are most at risk of severe infection, which can require high-flow nasal cannula and MV.